#Negative pressure wound therapy ncbi skin#
#Negative pressure wound therapy ncbi series#

#Negative pressure wound therapy ncbi skin#

A further specific property lies in the ability of a vacuum pressure to act as an effective skin graft splint over irregular surfaces 10, 27, 28, 29, 30, 31. These include increased dermal perfusion 14, 18, 19, 20, stimulation of granulation tissue formation 14, 21, 22, 23, reduction in oedema and interstitial tissue fluid (14), reverse tissue expansion (16) and reduced bacterial colonisation 16, 24, 25, 26. A comprehensive review of the multimodal action of TNP is beyond the scope of this article however, a number of scientific and clinical studies collectively support several mechanisms as central to the function of TNP. The use of TNP has been described as an adjunctive therapy to the pre‐ or postoperative surgical patient or as an alternative to surgery in a debilitated patient (15). In the case of infected wounds, TNP therapy may also be used with an irrigation system to facilitate the instillation of local antibiotic or antiseptic solutions (17). Much time has been spent studying the effects of varying the dressing substrate, the magnitude of the negative pressure applied and the pressure treatment cycle for specific indications. The concept of applying a suction force across a wound using a dressing interface is patented and is commercially available as vacuum‐assisted closure (VAC Kinetic Concepts, Inc., San Antonio, TX, USA) (16). The recent development of TRAC technology has allowed close control of the pressure exerted at the wound‐dressing interface via a feedback device. The application of subatmospheric pressure may be continuous or intermittent and the magnitude of the vacuum can be varied. The evolution of negative pressure from drainage tool to healing modality in its own right was popularised by Fleischmann and Argenta.įoam has proven critical for the transmission of subatmospheric pressure throughout the dressing (15) and hence a uniform mechanical force across the wound.

#Negative pressure wound therapy ncbi series#

This facility has allowed a more structured and scientific study of TNP, and in 1997, in a series of animal studies, Morykwas and Argenta were the first to detail the value of polyurethane sponge at the wound suction interface and to systematically investigate the physiological basis for observed clinical effects (14). In 1995, the development of microprocessor‐controlled commercial systems allowed the delivery of a programmable level of continuous or intermittent subatmospheric pressure at the wound surface. in 1993 and several clinical studies using a variety of systems and designs followed 7, 8, 9, 10, 11, 12, 13. The practice of exposing a wound to subatmospheric pressure for an extended period to promote debridement and healing was first described by Fleischmann et al. TNP achieves both, that is removes excess fluid and transmits mechanical forces to the surrounding tissue with resultant deformation of the extracellular matrix and cells (6). Furthermore, the positive manipulation of tissue growth by applied mechanical forces is well established, as in osteogenic distraction and soft tissue expansion. It has long been suggested that components of excess wound fluid may serve as both physical and chemical deterrents to wound healing (5). This treatment is called “ debridement.”Īn extra treatment called negative pressure wound therapy (also referred to as vacuum-assisted closure or VAC therapy) may be recommended for some wounds.The promotion of surgical wound healing through localised suction drainage is accepted practice 4, 5. Dead or inflamed tissue is removed as well. Inflamed or chronic wounds are cleaned regularly. Wounds that don’t close after several weeks despite treatment are considered to be chronic. They are used to keep the wound clean, protect it from infection and help it to heal. Different kinds of dressings made of various materials may be used depending on the type of wound. Wounds that can’t be closed directly because of their size or an inflammation can be treated with a wound dressing. The edges of larger wounds can be sewn together, or closed with staples or adhesives, and then treated with a wound dressing. Usually just an adhesive bandage is needed as a wound dressing for smaller wounds, which then close on their own. Wounds are typically cleaned and then closed. Some studies suggest that this treatment can help wounds heal better.

Negative pressure wound therapy can be used to help close poorly healing wounds and certain types of surgical wounds.